Blar i forfatter "Townsend, Jeffrey P."

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    • Assessing the probability of detection of horizontal gene transfer events in bacterial populations 

      Townsend, Jeffrey P.; Bøhn, Thomas; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Experimental approaches to identify horizontal gene transfer (HGT) events of non-mobile DNA in bacteria have typically relied on detection of the initial transformants or their immediate offspring. However, rare HGT events occurring in large and structured populations are unlikely to be detected in a short time frame. Population genetic modeling of the growth dynamics of bacterial genotypes is ...

    • Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains 

      Tekle, Yonas I.; Nielsen, Kaare Magne; Liu, Jingzhou; Pettigrew, Melinda M.; Meyers, Lauren A.; Galvani, Alison P.; Townsend, Jeffrey P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Vaccination has proven effective in controlling many infectious diseases. However, differential effectiveness with regard to pathogen genotype is a frequent reason for failures in vaccine development. Often, insufficient immune response is induced to prevent infection by the diversity of existing serotypes present in pathogenic populations of bacteria. These vaccines that target a too narrow spectrum ...

    • Detecting rare gene transfer events in bacterial populations 

      Nielsen, Kåre Magne; Bøhn, Thomas; Townsend, Jeffrey P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)